This is a combination of Paracetamol and Caffeine. Paracetamol has analgesic andantipyretic properties with weak anti-inflammatory activity. Caffeine is an alkaloid whichis a theophylline-like xanthine derivative. By intermolecular association withParacetamol, Caffeine increases the solubility and transmembrane permeation ofParacetamol. In addition, Caffeine increases the pain threshold and tolerance of pain.

Caffeine has also an intrinsic power to raise vessel tone in the brain, which provides another benefit to treat migraine and headache.